IPR004443
YjeF N-terminal domain
InterPro entry
Short name | YjeF_N_dom |
Overlapping homologous superfamilies |
Description
In bacteria or archaea, YjeF N-terminal domains occur either as single domain proteins or fused with other domains and are commonly associated with enzymes. YjeF N-terminal domains (also known as NAD(P)H-hydrate epimerase) are often fused to a YjeF C-terminal domain. It is a bifunctional enzyme that catalyses the epimerisation of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP
[1].
References
1.Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. Marbaix AY, Noel G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL. J. Biol. Chem. 286, 41246-52, (2011). View articlePMID: 21994945
Further reading
2. Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability. Anantharaman V, Aravind L. BMC Genomics 5, 45, (2004). View articlePMID: 15257761
Cross References
ENZYME
Genome Properties
Representative structure
1jzt: Crystal structure of yeast ynu0, YNL200c