IPR004450
Threonine synthase-like
InterPro entry
Short name | Thr_synthase-like |
Overlapping homologous superfamilies | |
family relationships |
Description
Threonine synthase (
4.2.3.1) is involved in threonine biosynthesis. It catalyses the conversion of O-phospho-L-homoserine and water into L-threonine and orthophosphate, using pyridoxal phosphate as a cofactor. The pyridoxal-phosphate binding site is a Lys (K) residue. The enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes
[1].
This entry includes threonine synthases and its homologues (threonine synthases like proteins) from archaea, bacteria, fungi, plants and metazoans. The function of the threonine synthase-like proteins from metazoan is still not clear
[2].
References
1.Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and D-serine dehydratase. Parsot C. EMBO J. 5, 3013-9, (1986). View articlePMID: 3098560
2.A threonine synthase homolog from a mammalian genome. Donini S, Percudani R, Credali A, Montanini B, Sartori A, Peracchi A. Biochem. Biophys. Res. Commun. 350, 922-8, (2006). View articlePMID: 17034760
Cross References
ENZYME
Genome Properties
Contributing Member Database Entry
- NCBIfam:TIGR00260
Representative structure
2zsj: Crystal structure of threonine synthase from Aquifex aeolicus VF5