F
IPR004563

Apolipoprotein N-acyltransferase

InterPro entry
Short nameApolipo_AcylTrfase
Overlapping
homologous
superfamilies
 

Description

Apolipoprotein N-acyltransferase (Lnt) transfers the acyl group to lipoproteins and is involved in lipoprotein biosynthesis in Gram-negative bacteria. It is an integral membrane protein
[2]
. In the last step of lipoprotein maturation, N-acylation by apolipoprotein N-acyltransferase of the plasma membrane is required for recognition of the outer membrane lipoproteins by the Lol system, which transports the lipoproteins from the plasma to the outer membrane
[1]
. This is a reverse amidase (i.e. condensation) reaction.

References

1.Depletion of apolipoprotein N-acyltransferase causes mislocalization of outer membrane lipoproteins in Escherichia coli. Robichon C, Vidal-Ingigliardi D, Pugsley AP. J. Biol. Chem. 280, 974-83, (2005). View articlePMID: 15513925

2.Identification of essential residues in apolipoprotein N-acyl transferase, a member of the CN hydrolase family. Vidal-Ingigliardi D, Lewenza S, Buddelmeijer N. J. Bacteriol. 189, 4456-64, (2007). View articlePMID: 17416655

Further reading

3. The nitrilase superfamily: classification, structure and function. Pace HC, Brenner C. Genome Biol. 2, REVIEWS0001, (2001). View articlePMID: 11380987

4. A new family of carbon-nitrogen hydrolases. Bork P, Koonin EV. Protein Sci. 3, 1344-6, (1994). View articlePMID: 7987228

GO terms

Cross References

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