F
IPR004621

Eukaryotic-type methylenetetrahydrofolate reductase

InterPro entry
Short nameFadh2_euk
Overlapping
homologous
superfamilies
 
family relationships

Description

This entry represents a family that includes methylenetetrahydrofolate reductase.

The enzyme activities methylenetetrahydrofolate reductase (
1.5.1.20
) and 5,10-methylenetetrahydrofolate reductase (FADH) (
1.7.99.5
) differ in that the former (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while the latter (assigned in many bacteria) is flexible with respect to the acceptor. Both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as one or the other, this family describes the subset of proteins found in eukaryotes, and currently designated methylenetetrahydrofolate reductase(
1.5.1.20
). This protein is an FAD-containing flavoprotein.

GO terms

Cross References

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.