F
IPR004912

Adenoviral core protein VII

InterPro entry
Short nameAdeno_VII

Description

Adenoviruses encode a highly basic protein called protein VII that resembles cellular histones. Protein VII forms complexes with nucleosomes, limiting DNA accessibility, and sequesters protein HMGB1 in the chromatin. HMGB1 is normally released in response to inflammatory stimuli and mediates activation of immune responses. This is thought to be part of a viral strategy to control extracellular immune signaling
[2]
. Protein VII also plays a role in packaging the viral DNA
[1]
.

References

1.Adenoviral protein VII packages intracellular viral DNA throughout the early phase of infection. Chatterjee PK, Vayda ME, Flint SJ. EMBO J. 5, 1633-44, (1986). View articlePMID: 3743550

2.A core viral protein binds host nucleosomes to sequester immune danger signals. Avgousti DC, Herrmann C, Kulej K, Pancholi NJ, Sekulic N, Petrescu J, Molden RC, Blumenthal D, Paris AJ, Reyes ED, Ostapchuk P, Hearing P, Seeholzer SH, Worthen GS, Black BE, Garcia BA, Weitzman MD. Nature 535, 173-7, (2016). View articlePMID: 27362237

GO terms

biological process

  • None

molecular function

  • None

cellular component

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