IPR005161
Ku70/Ku80, N-terminal alpha/beta
InterPro entry
Short name | Ku_N |
Overlapping homologous superfamilies |
Description
The Ku heterodimer (composed of Ku70
P12956 and Ku80
P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the N-terminal α/β domain. This domain only makes a small contribution to the dimer interface. The domain comprises a six stranded β sheet of the Rossman fold
[1].
References
1.A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. Sugihara T, Wadhwa R, Kaul SC, Mitsui Y. Genomics 57, 130-6, (1999). View articlePMID: 10191092
Cross References
Contributing Member Database Entry
- Pfam:PF03731
Representative structure
6tyu: Structure of Ku80 von Willebrand domain complexed with MRI Ku Binding Motif