D
IPR005161

Ku70/Ku80, N-terminal alpha/beta

InterPro entry
Short nameKu_N
Overlapping
homologous
superfamilies
 

Description

The Ku heterodimer (composed of Ku70
P12956
and Ku80
P13010
) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the N-terminal α/β domain. This domain only makes a small contribution to the dimer interface. The domain comprises a six stranded β sheet of the Rossman fold
[1]
.

References

1.A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. Sugihara T, Wadhwa R, Kaul SC, Mitsui Y. Genomics 57, 130-6, (1999). View articlePMID: 10191092

Cross References

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