F
IPR005338

Anhydro-N-acetylmuramic acid kinase

InterPro entry
Short nameAnhydro_N_Ac-Mur_kinase
Overlapping
homologous
superfamilies
 

Description

This entry represents the enzyme Anhydro-N-acetylmuramic acid kinase, predominantly found in bacteria. This protein catalyses the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. It is also required for the utilisation of anhMurNAc, either imported from the medium, or derived from its own cell wall murein, and in so doing plays a role in cell wall recycling
[1, 2]
.

This family also includes Levoglucosan kinase from the oleaginous yeast Lipomyces starkeyi, which catalyses the transfer of a phosphate group from ATP to levoglucosan (1,6-anhydro-beta-D-glucopyranose, LG) to yield glucose 6-phosphate in the presence of magnesium ion and ATP
[3, 4]
.

References

1.Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate. Uehara T, Suefuji K, Valbuena N, Meehan B, Donegan M, Park JT. J. Bacteriol. 187, 3643-9, (2005). View articlePMID: 15901686

2.MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall. Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT. J. Bacteriol. 188, 1660-2, (2006). View articlePMID: 16452451

3.Engineering ethanologenic Escherichia coli for levoglucosan utilization. Layton DS, Ajjarapu A, Choi DW, Jarboe LR. Bioresour Technol 102, 8318-22, (2011). PMID: 21719279

4.Producing glucose 6-phosphate from cellulosic biomass: structural insights into levoglucosan bioconversion. Bacik JP, Klesmith JR, Whitehead TA, Jarboe LR, Unkefer CJ, Mark BL, Michalczyk R. J Biol Chem 290, 26638-48, (2015). PMID: 26354439

GO terms

Cross References

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