D
IPR005490

L,D-transpeptidase catalytic domain

InterPro entry
Short nameLD_TPept_cat_dom
Overlapping
homologous
superfamilies
 

Description

This family of proteins are found in a range of bacteria. The conserved region contains a conserved histidine and cysteine, suggesting that these proteins have an enzymatic activity. Several members of this family contain peptidoglycan binding domains. So these proteins may use peptidoglycan or a precursor as a substrate.

References

1. Crystal structure of a novel beta-lactam-insensitive peptidoglycan transpeptidase. Biarrotte-Sorin S, Hugonnet JE, Delfosse V, Mainardi JL, Gutmann L, Arthur M, Mayer C. J. Mol. Biol. 359, 533-8, (2006). View articlePMID: 16647082

2. B. subtilis ykuD protein at 2.0 A resolution: insights into the structure and function of a novel, ubiquitous family of bacterial enzymes. Bielnicki J, Devedjiev Y, Derewenda U, Dauter Z, Joachimiak A, Derewenda ZS. Proteins 62, 144-51, (2006). View articlePMID: 16287140

3. Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli. Caveney NA, Caballero G, Voedts H, Niciforovic A, Worrall LJ, Vuckovic M, Fonvielle M, Hugonnet JE, Arthur M, Strynadka NCJ. Nat Commun 10, 1849, (2019). PMID: 31015395

4. The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of L,D-Carboxypeptidase. Kim HS, Im HN, An DR, Yoon JY, Jang JY, Mobashery S, Hesek D, Lee M, Yoo J, Cui M, Choi S, Kim C, Lee NK, Kim SJ, Kim JY, Bang G, Han BW, Lee BI, Yoon HJ, Suh SW. J Biol Chem 290, 25103-17, (2015). PMID: 26306031

5. Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis. Brammer Basta LA, Ghosh A, Pan Y, Jakoncic J, Lloyd EP, Townsend CA, Lamichhane G, Bianchet MA. J Biol Chem 290, 25670-85, (2015). PMID: 26304120

6. Specificity of L,D-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes. Magnet S, Arbeloa A, Mainardi JL, Hugonnet JE, Fourgeaud M, Dubost L, Marie A, Delfosse V, Mayer C, Rice LB, Arthur M. J Biol Chem 282, 13151-9, (2007). View articlePMID: 17311917

7. Peptidoglycan binding by a pocket on the accessory NTF2-domain of Pgp2 directs helical cell shape of Campylobacter jejuni. Lin CS, Chan ACK, Vermeulen J, Brockerman J, Soni AS, Tanner ME, Gaynor EC, McIntosh LP, Simorre JP, Murphy MEP. J Biol Chem 296, 100528, (2021). View articlePMID: 33711341

8. The l,d-Transpeptidase Ldt<sub>Ab</sub> from <i>Acinetobacter baumannii</i> Is Poorly Inhibited by Carbapenems and Has a Unique Structural Architecture. Toth M, Stewart NK, Smith CA, Lee M, Vakulenko SB. ACS Infect Dis 8, 1948-1961, (2022). View articlePMID: 35973205

GO terms

biological process

  • None

cellular component

  • None

Cross References

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