F
IPR005556

SUN family

InterPro entry
Short nameSUN

Description

This entry represents the Sun family from fungi. In budding yeasts there are four identified members: Nca3, Sim1, Sun4 and Uth. They hey share a common C-terminal domain of 258 amino acids bearing 75-85% identity. These C-terminal regions comprise a putative Fe-binding domain consisting in Cys residues organised in a Cys-X5-Cys-X3-Cys-X24-Cys motif
[2]
. Despite this remarkable homology, the SUN family members have been linked to various, often unrelated cellular processes such as those connected to mitochondrial and cell wall functions. Interestingly, they seem to be involved in the remodelling of the yeast cell wall during the various phases of yeast culture development and under various environmental conditions
[1]
.

References

1.SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level. Kuznetsov E, Kucerova H, Vachova L, Palkova Z. PLoS ONE 8, e73882, (2013). View articlePMID: 24040106

2.Dual cell wall/mitochondria localization of the 'SUN' family proteins. Velours G, Boucheron C, Manon S, Camougrand N. FEMS Microbiol. Lett. 207, 165-72, (2002). View articlePMID: 11958935

Cross References

Contributing Member Database Entry
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