F
IPR005584

DNA gyrase inhibitor YacG

InterPro entry
Short nameDNA_gyrase_inhibitor_YacG
Overlapping
homologous
superfamilies
 

Description

This entry represents the DNA gyrase inhibitor YacG family. E coli. YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
[2]
. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins
[1]
. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures.

References

1.NMR structure of the Escherichia coli protein YacG: a novel sequence motif in the zinc-finger family of proteins. Ramelot TA, Cort JR, Yee AA, Semesi A, Edwards AM, Arrowsmith CH, Kennedy MA. Proteins 49, 289-93, (2002). View articlePMID: 12211008

2.YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyrase. Sengupta S, Nagaraja V. Nucleic Acids Res. 36, 4310-6, (2008). View articlePMID: 18586829

GO terms

biological process

  • None

cellular component

  • None
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