UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD
Short name | MurD |
family relationships |
Description
* (1) formation of UDP-N-acetylmuramic acid (UDPMurNAc) from N-acetylglucosamine (GlcNAc).
* (2) addition of a short polypeptide chain to the UDPMurNAc.
* (3) addition of a second GlcNAc to the disaccharide-pentapeptide building block and transport of this unit through the cytoplasmic membrane and incorporation into the growing peptidoglycan layer.
References
1.Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC). Deva T, Baker EN, Squire CJ, Smith CA. Acta Crystallogr. D Biol. Crystallogr. 62, 1466-74, (2006). View articlePMID: 17139082
2.Targeted molecular dynamics simulation studies of binding and conformational changes in E. coli MurD. Perdih A, Kotnik M, Hodoscek M, Solmajer T. Proteins 68, 243-54, (2007). View articlePMID: 17427948
3.The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity. Boniface A, Bouhss A, Mengin-Lecreulx D, Blanot D. J. Biol. Chem. 281, 15680-6, (2006). View articlePMID: 16595662
4.Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure. Longenecker KL, Stamper GF, Hajduk PJ, Fry EH, Jakob CG, Harlan JE, Edalji R, Bartley DM, Walter KA, Solomon LR, Holzman TF, Gu YG, Lerner CG, Beutel BA, Stoll VS. Protein Sci. 14, 3039-47, (2005). View articlePMID: 16322581
5.Structure, function and dynamics in the mur family of bacterial cell wall ligases. Smith CA. J. Mol. Biol. 362, 640-55, (2006). View articlePMID: 16934839
6.The MurC ligase essential for peptidoglycan biosynthesis is regulated by the serine/threonine protein kinase PknA in Corynebacterium glutamicum. Fiuza M, Canova MJ, Patin D, Letek M, Zanella-Cleon I, Becchi M, Mateos LM, Mengin-Lecreulx D, Molle V, Gil JA. J Biol Chem 283, 36553-63, (2008). PMID: 18974047
GO terms
biological process
molecular function
cellular component
Cross References
ENZYME
Genome Properties