D
IPR005805

Rieske iron-sulphur protein, C-terminal

InterPro entry
Short nameRieske_Fe-S_prot_C
Overlapping
homologous
superfamilies
 
domain relationships

Description

Ubiquinol-cytochrome c reductase (bc1 complex or complex III) is an enzyme complex of bacterial and mitochondrial oxidative phosphorylation systems It catalyses the oxidoreduction of the mobile redox components ubiquinol and cytochrome c, generating an electrochemical potential, which is linked to ATP synthesis
[1, 2]
. The complex consists of three subunits in most bacteria, and nine in mitochondria: both bacterial and mitochondrial complexes contain cytochrome b and cytochrome c1 subunits, and an iron-sulphur `Rieske' subunit, which contains a high potential 2Fe-2S cluster
[3]
.The mitochondrial form also includes six other subunits that do not possess redox centres. Plastoquinone-plastocyanin reductase (b6f complex), cyanobacteria and the chloroplasts of plants, catalyses the oxidoreduction of plastoquinol and cytochrome f. This complex, which is functionally similar to ubiquinol-cytochrome c reductase, comprises cytochrome b6, cytochrome f and Rieske subunits
[4]
.

The Rieske subunit acts by binding either a ubiquinol or plastoquinol anion, transferring an electron to the 2Fe-2S cluster, then releasing the electron to the cytochrome c or cytochrome f haem iron
[1, 4]
. The 2Fe-2S cluster is bound in the highly conserved C-terminal region of the Rieske subunit.

References

1.The primary structure of the iron-sulfur subunit of ubiquinol-cytochrome c reductase from Neurospora, determined by cDNA and gene sequencing. Harnisch U, Weiss H, Sebald W. Eur. J. Biochem. 149, 95-9, (1985). View articlePMID: 2986972

2.Nucleotide sequence and transcription of the fbc operon from Rhodopseudomonas sphaeroides. Evaluation of the deduced amino acid sequences of the FeS protein, cytochrome b and cytochrome c1. Gabellini N, Sebald W. Eur. J. Biochem. 154, 569-79, (1986). View articlePMID: 3004982

3.The genes of the Paracoccus denitrificans bc1 complex. Nucleotide sequence and homologies between bacterial and mitochondrial subunits. Kurowski B, Ludwig B. J. Biol. Chem. 262, 13805-11, (1987). View articlePMID: 2820981

4.Import and processing of the precursor of the Rieske FeS protein of tobacco chloroplasts. Madueno F, Napier JA, Cejudo FJ, Gray JC. Plant Mol. Biol. 20, 289-99, (1992). View articlePMID: 1391772

GO terms

biological process

  • None

cellular component

Cross References

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