IPR005815
Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA
InterPro entry
Short name | BioA |
Overlapping homologous superfamilies | |
family relationships |
Description
BioA is an adenosylmethionine-8-amino-7-oxononanoate aminotransferase that functions in biotin synthesis. It utilises S-adenosyl-L-methionine (SAM) to transaminate the biotin precursor 7-keto-8-aminopelargonic acid and form the next intermediate in the pathway, 7, 8-diaminopelargonic acid
[1]. It is currently the only aminotransferase that is known to use SAM as an amino donor. The Bacillus subtilis enzyme, which is included in this entry, uses lysine rather than SAM as the amino donor
[2].
References
1.Purification and properties of 7, 8-diaminopelargonic acid aminotransferase. Stoner GL, Eisenberg MA. J. Biol. Chem. 250, 4029-36, (1975). PMID: 1092681
2.Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction. Van Arsdell SW, Perkins JB, Yocum RR, Luan L, Howitt CL, Chatterjee NP, Pero JG. Biotechnol. Bioeng. 91, 75-83, (2005). View articlePMID: 15880481
GO terms
biological process
cellular component
- None
Cross References
ENZYME
Genome Properties