F
IPR005815

Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA

InterPro entry
Short nameBioA
Overlapping
homologous
superfamilies
 
family relationships

Description

BioA is an adenosylmethionine-8-amino-7-oxononanoate aminotransferase that functions in biotin synthesis. It utilises S-adenosyl-L-methionine (SAM) to transaminate the biotin precursor 7-keto-8-aminopelargonic acid and form the next intermediate in the pathway, 7, 8-diaminopelargonic acid
[1]
. It is currently the only aminotransferase that is known to use SAM as an amino donor. The Bacillus subtilis enzyme, which is included in this entry, uses lysine rather than SAM as the amino donor
[2]
.

References

1.Purification and properties of 7, 8-diaminopelargonic acid aminotransferase. Stoner GL, Eisenberg MA. J. Biol. Chem. 250, 4029-36, (1975). PMID: 1092681

2.Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction. Van Arsdell SW, Perkins JB, Yocum RR, Luan L, Howitt CL, Chatterjee NP, Pero JG. Biotechnol. Bioeng. 91, 75-83, (2005). View articlePMID: 15880481

GO terms

Cross References

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