D
IPR005821

Ion transport domain

InterPro entry
Short nameIon_trans_dom
Overlapping
homologous
superfamilies
 

Description

This domain is found in sodium, potassium, and calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channel proteins the domain is repeated four times, whereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.

This domain is also found in Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1/2/3 that upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER)
[2, 1]
.

References

1.Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome. Gerber S, Alzayady KJ, Burglen L, Bremond-Gignac D, Marchesin V, Roche O, Rio M, Funalot B, Calmon R, Durr A, Gil-da-Silva-Lopes VL, Ribeiro Bittar MF, Orssaud C, Heron B, Ayoub E, Berquin P, Bahi-Buisson N, Bole C, Masson C, Munnich A, Simons M, Delous M, Dollfus H, Boddaert N, Lyonnet S, Kaplan J, Calvas P, Yule DI, Rozet JM, Fares Taie L. Am J Hum Genet 98, 971-980, (2016). View articlePMID: 27108797

2.Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors. Adkins CE, Morris SA, De Smedt H, Sienaert I, Torok K, Taylor CW. Biochem J 345 Pt 2, 357-63, (2000). PMID: 10620513

GO terms

Cross References

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