IPR005821
Ion transport domain
InterPro entry
Short name | Ion_trans_dom |
Overlapping homologous superfamilies |
Description
This domain is found in sodium, potassium, and calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channel proteins the domain is repeated four times, whereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.
References
1.Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome. Gerber S, Alzayady KJ, Burglen L, Bremond-Gignac D, Marchesin V, Roche O, Rio M, Funalot B, Calmon R, Durr A, Gil-da-Silva-Lopes VL, Ribeiro Bittar MF, Orssaud C, Heron B, Ayoub E, Berquin P, Bahi-Buisson N, Bole C, Masson C, Munnich A, Simons M, Delous M, Dollfus H, Boddaert N, Lyonnet S, Kaplan J, Calvas P, Yule DI, Rozet JM, Fares Taie L. Am J Hum Genet 98, 971-980, (2016). View articlePMID: 27108797
GO terms
molecular function
cellular component
Cross References
Contributing Member Database Entry
- Pfam:PF00520
Representative structure
1ors: X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab