F
IPR006129

Adhesin B

InterPro entry
Short nameAdhesinB
family relationships

Description

The Streptococcus pneumoniae psaA gene encodes a protein with significant similarity to previously-reported Streptococcal proteins, SsaB (80% similarity) and FimA (92.3% similarity), from Streptococcus sanguis and Streptococcus parasanguis
[1]
. These homologues are associated with bacterial adhesion, and PsaA may play a similar role
[1]
.

The SsaB protein has a putative hydrophobic 19-amino-acid signal sequence yielding a 32,620-Mr secreted protein
[2]
. SsaB is hydrophilic and appears not to have a hydrophobic membrane anchor in its C-terminal region. A high degree of similarity exists between S. sanguis ssaB and type 1 fimbrial genes
[2]
. Comparison of the gene products reveals close similarity of the two proteins. It is thought that ssaB adhesion may play a role in oral colonisation by binding either to a receptor on saliva or to a receptor on Actinomyces.

This sub-family is described by from conserved regions spanning the full alignment length, focusing on those sections that characterise the adhesin B precursors but distinguish them from the rest of the adhesin family.

References

1.Cloning and nucleotide sequence analysis of psaA, the Streptococcus pneumoniae gene encoding a 37-kilodalton protein homologous to previously reported Streptococcus sp. adhesins. Sampson JS, O'Connor SP, Stinson AR, Tharpe JA, Russell H. Infect. Immun. 62, 319-24, (1994). View articlePMID: 7505262

2.Nucleotide sequence of a gene coding for a saliva-binding protein (SsaB) from Streptococcus sanguis 12 and possible role of the protein in coaggregation with actinomyces. Ganeshkumar N, Hannam PM, Kolenbrander PE, McBride BC. Infect. Immun. 59, 1093-9, (1991). View articlePMID: 1671775

GO terms

biological process

molecular function

  • None

cellular component

  • None
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