F
IPR006287

Protein/nucleic acid deglycase DJ-1

InterPro entry
Short nameDJ-1
Overlapping
homologous
superfamilies
 

Description

Glycation is a nonenzymatic covalent reaction between proteins and endogenous reducing sugars or dicarbonyls (methylglyoxal, glyoxal) that results in protein inactivation. DJ-1 was described in vitro as a protein deglycase that repaired methylglyoxal-and glyoxal-glycated proteins
[6, 8]
. Since then there have been reports against
[2]
, and supporting this role for DJ-1
[4]
. Furthermore, supporting its deglycase activity, DJ-1 and its bacterial homologues have been shown to be able to repair methylglyoxal-and glyoxal-glycated nucleotides and nucleic acids
[1]
. This ability would make DJ-1 a target for diabetic and cancer research
[3]
. DJ-1, also known as Park7, has been associated with human parkinsonism
[7]
.

Included in this family is also YajL from Escherichia coli, the bacterial homologue of DJ-1
[9, 5]
. This group of proteins are classified as either DJ-1 putative peptidases or non-peptidase homologues in MEROPS peptidase family C56 (clan PC(C)).

References

1.Guanine glycation repair by DJ-1/Park7 and its bacterial homologs. Richarme G, Liu C, Mihoub M, Abdallah J, Leger T, Joly N, Liebart JC, Jurkunas UV, Nadal M, Bouloc P, Dairou J, Lamouri A. Science 357, 208-211, (2017). View articlePMID: 28596309

2.Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification. Pfaff DH, Fleming T, Nawroth P, Teleman AA. J. Biol. Chem. 292, 685-690, (2017). View articlePMID: 27903648

3.Of sizzling steaks and DNA repair. Dingler FA, Patel KJ. Science 357, 130-131, (2017). View articlePMID: 28706026

4.Parkinsonism-associated protein DJ-1 is a bona fide deglycase. Richarme G, Dairou J. Biochem. Biophys. Res. Commun. 483, 387-391, (2017). View articlePMID: 28013050

5.The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal. Abdallah J, Mihoub M, Gautier V, Richarme G. Biochem. Biophys. Res. Commun. 470, 282-6, (2016). View articlePMID: 26774339

6.Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues. Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A. J. Biol. Chem. 290, 1885-97, (2015). View articlePMID: 25416785

7.Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P. Science 299, 256-9, (2003). View articlePMID: 12446870

8.The Parkinsonism-associated protein DJ-1/Park7 prevents glycation damage in human keratinocyte. Advedissian T, Deshayes F, Poirier F, Viguier M, Richarme G. Biochem. Biophys. Res. Commun. 473, 87-91, (2016). View articlePMID: 26995087

9.Translational defects in a mutant deficient in YajL, the bacterial homolog of the parkinsonism-associated protein DJ-1. Kthiri F, Gautier V, Le HT, Prere MF, Fayet O, Malki A, Landoulsi A, Richarme G. J. Bacteriol. 192, 6302-6, (2010). View articlePMID: 20889753

Cross References

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