F
IPR006322

Glutathione reductase, eukaryote/bacterial

InterPro entry
Short nameGlutathione_Rdtase_euk/bac
Overlapping
homologous
superfamilies
 
family relationships

Description

This entry represents glutathione reductase (GSHR or GRase) from bacteria, animals and fungi. This protein family is one of two closely related subfamilies of GRase, which are also closely related to trypanothione reductase. GRase regenerates glutathione disulphide and NADPH from oxidized glutathione and NADP. In mice, this dimeric enzyme is responsible for an effective innate immune response against bacteria
[2]
. In humans, it may be a target for improving the treatment of glioblastoma multiforme as it has been related to drug resistance in glioblastoma cells
[1]
.

References

1.Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis. Zhu Z, Du S, Du Y, Ren J, Ying G, Yan Z. J Neurochem 144, 93-104, (2018). PMID: 29105080

2.Glutathione reductase is essential for host defense against bacterial infection. Yan J, Ralston MM, Meng X, Bongiovanni KD, Jones AL, Benndorf R, Nelin LD, Joshua Frazier W, Rogers LK, Smith CV, Liu Y. Free Radic Biol Med 61, 320-32, (2013). PMID: 23623936

GO terms

Cross References

Contributing Member Database Entry
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