IPR006322
Glutathione reductase, eukaryote/bacterial
InterPro entry
Short name | Glutathione_Rdtase_euk/bac |
Overlapping homologous superfamilies | |
family relationships |
Description
This entry represents glutathione reductase (GSHR or GRase) from bacteria, animals and fungi. This protein family is one of two closely related subfamilies of GRase, which are also closely related to trypanothione reductase. GRase regenerates glutathione disulphide and NADPH from oxidized glutathione and NADP. In mice, this dimeric enzyme is responsible for an effective innate immune response against bacteria
[2]. In humans, it may be a target for improving the treatment of glioblastoma multiforme as it has been related to drug resistance in glioblastoma cells
[1].
References
GO terms
biological process
molecular function
cellular component
- None
Cross References
ENZYME
Genome Properties
Contributing Member Database Entry
- NCBIfam:TIGR01421
Representative structure
1k4q: Human Glutathione Reductase Inactivated by Peroxynitrite