F
IPR006449

Squalene synthase-like

InterPro entry
Short nameSqual_synth-like
Overlapping
homologous
superfamilies
 
family relationships

Description

This family of sequences describe farnesyl-diphosphate farnesyltransferase, also known as squalene synthase, as found in eukaryotes. This family is related to phytoene synthases. Tentatively identified archaeal homologues lack the C-terminal predicted transmembrane region universally conserved among members of this family and therefore are not included in this group.

This family also includes squalene synthase-like (SSL) proteins from green algae. SSL-3 (Botryococcene synthase) produces botryococcene when coexpressed with SSL-1 (Presqualene diphosphate synthase). SSL-3 has no activity with farnesyl diphosphate as substrate
[1]
. SSL-2 (Botryococcus squalene synthase) produces squalene when coexpressed with SSL-1 and bisfarnesyl ether
[1]
.

References

1.Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii. Niehaus TD, Okada S, Devarenne TP, Watt DS, Sviripa V, Chappell J. Proc. Natl. Acad. Sci. U.S.A. 108, 12260-5, (2011). View articlePMID: 21746901

Further reading

2. Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis. Pandit J, Danley DE, Schulte GK, Mazzalupo S, Pauly TA, Hayward CM, Hamanaka ES, Thompson JF, Harwood HJ Jr. J. Biol. Chem. 275, 30610-7, (2000). View articlePMID: 10896663

GO terms

Cross References

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