IPR006680
Amidohydrolase-related
InterPro entry
Short name | Amidohydro-rel |
Overlapping homologous superfamilies |
Description
Proteins containing this domain are enzymes from a large metal dependent hydrolase superfamily
[2]. The family includes adenine deaminase (
3.5.4.2) that hydrolyses adenine to form hypoxanthine and ammonia. This reaction is important for adenine utilisation as a purine and also as a nitrogen source
[1]. The entry also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases (
3.5.1.25). The domain is also found in the urease alpha subunit, where it is the catalytic domain
[3].
References
1.Role of adenine deaminase in purine salvage and nitrogen metabolism and characterization of the ade gene in Bacillus subtilis. Nygaard P, Duckert P, Saxild HH. J. Bacteriol. 178, 846-53, (1996). View articlePMID: 8550522
2.An evolutionary treasure: unification of a broad set of amidohydrolases related to urease. Holm L, Sander C. Proteins 28, 72-82, (1997). View articlePMID: 9144792
3.The crystal structure of urease from Klebsiella aerogenes. Jabri E, Carr MB, Hausinger RP, Karplus PA. Science 268, 998-1004, (1995). View articlePMID: 7754395
GO terms
Cross References
ENZYME
- 2.1.3.2
- 3.1.1.-
- 3.1.1.120
- 3.1.1.57
- 3.1.1.65
- 3.1.1.92
- 3.4.17.-
- 3.4.19.-
- 3.5.1.-
- 3.5.1.2
- 3.5.1.25
- 3.5.1.5
- 3.5.2.-
- 3.5.2.18
- 3.5.2.2
- 3.5.2.3
- 3.5.2.5
- 3.5.2.7
- 3.5.3.13
- 3.5.4.-
- 3.5.4.11
- 3.5.4.2
- 3.5.4.28
- 3.5.4.3
- 3.5.4.31
- 3.5.4.32
- 3.5.4.4
- 3.5.4.40
- 3.5.4.41
- 3.5.4.43
- 3.5.4.45
- 3.8.1.-
- 3.8.1.8
- 4.1.1.-
- 4.1.1.103
- 4.1.1.45
- 4.1.1.46
- 4.1.1.52
- 4.1.1.91
- 4.2.1.-
- 4.3.1.3
- 5.4.1.4
- 6.3.4.16
- 6.3.5.5