D
IPR006680

Amidohydrolase-related

InterPro entry
Short nameAmidohydro-rel
Overlapping
homologous
superfamilies
 

Description

Proteins containing this domain are enzymes from a large metal dependent hydrolase superfamily
[2]
. The family includes adenine deaminase (
3.5.4.2
) that hydrolyses adenine to form hypoxanthine and ammonia. This reaction is important for adenine utilisation as a purine and also as a nitrogen source
[1]
. The entry also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases (
3.5.1.25
). The domain is also found in the urease alpha subunit, where it is the catalytic domain
[3]
.

References

1.Role of adenine deaminase in purine salvage and nitrogen metabolism and characterization of the ade gene in Bacillus subtilis. Nygaard P, Duckert P, Saxild HH. J. Bacteriol. 178, 846-53, (1996). View articlePMID: 8550522

2.An evolutionary treasure: unification of a broad set of amidohydrolases related to urease. Holm L, Sander C. Proteins 28, 72-82, (1997). View articlePMID: 9144792

3.The crystal structure of urease from Klebsiella aerogenes. Jabri E, Carr MB, Hausinger RP, Karplus PA. Science 268, 998-1004, (1995). View articlePMID: 7754395

GO terms

biological process

  • None

cellular component

  • None

Cross References

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