AIG1-type guanine nucleotide-binding (G) domain
Short name | G_AIG1 |
Overlapping homologous superfamilies |
Description
* The GTPases of immunity-associated protein (GIMAP)/immune-associated nucleotide-binding protein (IAN) subfamily is conserved among vertebrates and angiosperm plants and has been postulated to regulate apoptosis, particularly in context with diseases such as cancer, diabetes, and infections. The function of GIMAP/IAN GTPases has been linked to self defense in plants and to the development of T cells in vertebrates
* Plant-specific Toc (translocon at the outer envelope membrane of chloroplasts) proteins. Toc proteins function as integral components of the chloroplast protein import machinery. The Toc translocon contains the two membrane-bound GTPases Toc33/34 and Toc 159, which expose their G domains to the cytosol and recognise and then deliver precursor proteins through the translocation pore Toc75
References
1.Classification and evolution of P-loop GTPases and related ATPases. Leipe DD, Wolf YI, Koonin EV, Aravind L. J. Mol. Biol. 317, 41-72, (2002). View articlePMID: 11916378
2.The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures. Koenig P, Oreb M, Hofle A, Kaltofen S, Rippe K, Sinning I, Schleiff E, Tews I. Structure 16, 585-96, (2008). View articlePMID: 18400179
3.Dimerization is important for the GTPase activity of chloroplast translocon components atToc33 and psToc159. Yeh YH, Kesavulu MM, Li HM, Wu SZ, Sun YJ, Konozy EH, Hsiao CD. J. Biol. Chem. 282, 13845-53, (2007). View articlePMID: 17337454
4.Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2). Schwefel D, Frohlich C, Eichhorst J, Wiesner B, Behlke J, Aravind L, Daumke O. Proc. Natl. Acad. Sci. U.S.A. 107, 20299-304, (2010). View articlePMID: 21059949
5.Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. Krucken J, Schroetel RM, Muller IU, Saidani N, Marinovski P, Benten WP, Stamm O, Wunderlich F. Gene 341, 291-304, (2004). View articlePMID: 15474311
GO terms
Cross References
ENZYME