IPR006754
Poxvirus I3 ssDNA-binding
InterPro entry
Short name | Poxvirus_I3_ssDNA-bd |
Description
The 34kDa protein encoded by the I3 gene of vaccinia virus, named Protein OPG079, is expressed at early and intermediate times post-infection and is phosphorylated on serine residues. I3 protein demonstrates a striking affinity for single-stranded, but not for double-stranded, DNA. Electrophoretic mobility shift assays indicate that numerous I3 molecules can bind to a template, reflecting the stoichiometric interaction of I3 with DNA. Sequence analysis reveals that a pattern of aromatic and charged amino acids common to many replicative single-stranded DNA binding proteins (SSBs) is conserved in I3
[1]. This protein plays an essential role in viral DNA replication
[2].
References
1.Characterization of the single-stranded DNA binding protein encoded by the vaccinia virus I3 gene. Rochester SC, Traktman P. J. Virol. 72, 2917-26, (1998). View articlePMID: 9525612
GO terms
biological process
- None
molecular function
cellular component
- None
Contributing Member Database Entries
- Pfam:PF04661
- PIRSF:PIRSF003767