F
IPR006761

Twisted gastrulation (Tsg) protein

InterPro entry
Short nameTsg

Description

Tsg was identified in Drosophila melanogaster as being required to specify the dorsal-most structures in the embryo, for example the amnioserosa. Biochemical experiments have revealed three key properties of Tsg:


 * it can synergistically inhibit Dpp/BMP action in both D. melanogaster and vertebrates by forming a tripartite complete between itself, SOG/chordin and a BMP ligand;
 * Tsg seems to enhance the Tld/BMP-1-mediated cleavage rate of SOG/chordin and may change the preference of site utilisation;
 * Tsg can promote the dissociation of chordin cysteine-rich-containing fragments from the ligand to inhibit BMP signalling
[1, 2]
.

References

1.Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor. Mason ED, Konrad KD, Webb CD, Marsh JL. Genes Dev. 8, 1489-501, (1994). View articlePMID: 7958834

2.Twisted gastrulation is a conserved extracellular BMP antagonist. Ross JJ, Shimmi O, Vilmos P, Petryk A, Kim H, Gaudenz K, Hermanson S, Ekker SC, O'Connor MB, Marsh JL. Nature 410, 479-83, (2001). View articlePMID: 11260716

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.