IPR006761
Twisted gastrulation (Tsg) protein
InterPro entry
Short name | Tsg |
Description
Tsg was identified in Drosophila melanogaster as being required to specify the dorsal-most structures in the embryo, for example the amnioserosa. Biochemical experiments have revealed three key properties of Tsg:
* it can synergistically inhibit Dpp/BMP action in both D. melanogaster and vertebrates by forming a tripartite complete between itself, SOG/chordin and a BMP ligand;
* Tsg seems to enhance the Tld/BMP-1-mediated cleavage rate of SOG/chordin and may change the preference of site utilisation;
* Tsg can promote the dissociation of chordin cysteine-rich-containing fragments from the ligand to inhibit BMP signalling
.
References
1.Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor. Mason ED, Konrad KD, Webb CD, Marsh JL. Genes Dev. 8, 1489-501, (1994). View articlePMID: 7958834
2.Twisted gastrulation is a conserved extracellular BMP antagonist. Ross JJ, Shimmi O, Vilmos P, Petryk A, Kim H, Gaudenz K, Hermanson S, Ekker SC, O'Connor MB, Marsh JL. Nature 410, 479-83, (2001). View articlePMID: 11260716