D
IPR006768

Cwf19-like, C-terminal domain-1

InterPro entry
Short nameCwf19-like_C_dom-1

Description

This group of sequences contain a conserved C-terminal domain which is found in the Schizosaccharomyces pombe (Fission yeast) protein Cwf19 (
Q09909
) and its homologues. Cwf19 is part of the Cdc5p complex involved in mRNA splicing
[1]
. CWF19-like protein DRN1 from Saccharomyces cerevisiae (
P53255
) is involved branched RNA metabolism, modulating the turnover of lariat-intron pre-mRNAs by the lariat-debranching enzyme DBR1 (
P53255
)
[2]
. This domain is found in association with
IPR006767
, which is generally C-terminal and adjacent to this domain. These domains contain evolutionarily conserved cysteine and histidine residues in an arrangement similar to the CCCH-class of zinc fingers
[2]
.

References

1.Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. Ohi MD, Link AJ, Ren L, Jennings JL, McDonald WH, Gould KL. Mol. Cell. Biol. 22, 2011-24, (2002). View articlePMID: 11884590

2.A homolog of lariat-debranching enzyme modulates turnover of branched RNA. Garrey SM, Katolik A, Prekeris M, Li X, York K, Bernards S, Fields S, Zhao R, Damha MJ, Hesselberth JR. RNA 20, 1337-48, (2014). View articlePMID: 24919400

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