IPR006805
Anthranilate synthase component I, N-terminal
InterPro entry
Short name | Anth_synth_I_N |
Overlapping homologous superfamilies |
Description
Anthranilate synthase catalyses the first step in the biosynthesis of tryptophan. Component I catalyses the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (
IPR005801). This region is involved in feedback inhibition by tryptophan
[1]. This family also contains a region of Para-aminobenzoate synthase component I.
References
1.The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Spraggon G, Kim C, Nguyen-Huu X, Yee MC, Yanofsky C, Mills SE. Proc. Natl. Acad. Sci. U.S.A. 98, 6021-6, (2001). View articlePMID: 11371633
GO terms
Cross References
Contributing Member Database Entry
- Pfam:PF04715