D
IPR006953

Vesicle tethering protein Uso1/P115-like, head domain

InterPro entry
Short nameVesicle_Uso1_P115_head
Overlapping
homologous
superfamilies
 

Description

This domain identifies a group of proteins, which are described as: General vesicular transport factor, Transcytosis associated protein (TAP) or Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region
[1]
. p115 tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal acidic region. It is required for intercisternal transport in the Golgi stack. This domain is found in the head region. The head region is highly conserved, but its function is unknown. It does not seem to be essential for vesicle tethering
[1]
. The N-terminal part of the head region contains context-detected Armadillo/beta-catenin-like repeats.

References

1.Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115. Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G. J. Cell Biol. 157, 45-62, (2002). View articlePMID: 11927603

GO terms

Contributing Member Database Entry
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