D
IPR006972

Translocator protein BipB-like, C-terminal domain

InterPro entry
Short nameBipB-like_C

Description

This entry represents the C-terminal domain of Translocator protein BipB from Burkholderia pseudomallei and similar proteins predominantly found in proteobacteria. BipB plays a role in the bacterium-induced formation of multinucleated giant cell (MNGC), which is formed after host cell fusion, as well as in the intercellular spreading of bacteria and in the induction of apoptosis in macrophages
[1]
. This domain covers most of the protein sequence in SPI-2 type 3 secretion system translocon protein SctE from Salmonella typhimurium, a component of the type III secretion system 2 (SPI-2 T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (Probable). SseC/SctE2 and SseD/SctB2 are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells
[2, 3]
.

References

1.Multinucleated giant cell formation and apoptosis in infected host cells is mediated by Burkholderia pseudomallei type III secretion protein BipB. Suparak S, Kespichayawattana W, Haque A, Easton A, Damnin S, Lertmemongkolchai G, Bancroft GJ, Korbsrisate S. J. Bacteriol. 187, 6556-60, (2005). View articlePMID: 16159789

2.SseBCD proteins are secreted by the type III secretion system of Salmonella pathogenicity island 2 and function as a translocon. Nikolaus T, Deiwick J, Rappl C, Freeman JA, Schroder W, Miller SI, Hensel M. J Bacteriol 183, 6036-45, (2001). View articlePMID: 11567004

3.Identification of Salmonella SPI-2 secretion system components required for SpvB-mediated cytotoxicity in macrophages and virulence in mice. Browne SH, Hasegawa P, Okamoto S, Fierer J, Guiney DG. FEMS Immunol. Med. Microbiol. 52, 194-201, (2008). View articlePMID: 18248436

Further reading

4. Theory of RNA-DNA hybridization--I. Stoichiometry at equilibrium. Reiner JM. Bull. Math. Biol. 37, 225-68, (1975). View articlePMID: 1156700

5. Characterization of translocation pores inserted into plasma membranes by type III-secreted Esp proteins of enteropathogenic Escherichia coli. Ide T, Laarmann S, Greune L, Schillers H, Oberleithner H, Schmidt MA. Cell. Microbiol. 3, 669-79, (2001). View articlePMID: 11580752

Cross References

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