IPR007150
Checkpoint protein Hus1/Mec3
InterPro entry
Short name | Hus1/Mec3 |
family relationships |
Description
This entry consists of the human Hus1 protein and budding yeast Mec3. They are components of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes
[2, 1].
References
1.Molecular analysis of hus1+, a fission yeast gene required for S-M and DNA damage checkpoints. Kostrub CF, al-Khodairy F, Ghazizadeh H, Carr AM, Enoch T. Mol. Gen. Genet. 254, 389-99, (1997). View articlePMID: 9180692
Further reading
3. 9-1-1: PCNA's specialized cousin. Eichinger CS, Jentsch S. Trends Biochem. Sci. 36, 563-8, (2011). View articlePMID: 21978893
4. The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast. Longhese MP, Paciotti V, Fraschini R, Zaccarini R, Plevani P, Lucchini G. EMBO J. 16, 5216-26, (1997). View articlePMID: 9311982
GO terms
biological process
molecular function
- None
cellular component
Contributing Member Database Entry
- Pfam:PF04005