F
IPR007150

Checkpoint protein Hus1/Mec3

InterPro entry
Short nameHus1/Mec3
family relationships

Description

This entry consists of the human Hus1 protein and budding yeast Mec3. They are components of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes
[2, 1]
.

References

1.Molecular analysis of hus1+, a fission yeast gene required for S-M and DNA damage checkpoints. Kostrub CF, al-Khodairy F, Ghazizadeh H, Carr AM, Enoch T. Mol. Gen. Genet. 254, 389-99, (1997). View articlePMID: 9180692

2.Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway. Kondo T, Matsumoto K, Sugimoto K. Mol. Cell. Biol. 19, 1136-43, (1999). PMID: 9891048

Further reading

3. 9-1-1: PCNA's specialized cousin. Eichinger CS, Jentsch S. Trends Biochem. Sci. 36, 563-8, (2011). View articlePMID: 21978893

4. The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast. Longhese MP, Paciotti V, Fraschini R, Zaccarini R, Plevani P, Lucchini G. EMBO J. 16, 5216-26, (1997). View articlePMID: 9311982

GO terms

molecular function

  • None
Contributing Member Database Entry
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