F
IPR007440

Chorismate--pyruvate lyase

InterPro entry
Short nameChorismate--pyruvate_lyase
Overlapping
homologous
superfamilies
 

Description

Chorismate--pyruvate lyase catalyses the first step in ubiquinone synthesis, the removal of pyruvate from chorismate, to yield 4-hydroxybenzoate in Escherichia coli and other Gram-negative bacteria
[1]
. The yeast Saccharomyces cerevisiae can synthesize ubiquinone from either chorismate or tyrosine
[2]
, however this enzyme is found only in bacteria. Its activity does not require metal cofactors
[3]
.

References

1.Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase. Nichols BP, Green JM. J. Bacteriol. 174, 5309-16, (1992). View articlePMID: 1644758

2.Ubiquinone biosynthesis in microorganisms. Meganathan R. FEMS Microbiol. Lett. 203, 131-9, (2001). View articlePMID: 11583838

3.Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase. Siebert M, Severin K, Heide L. Microbiology (Reading, Engl.) 140 ( Pt 4), 897-904, (1994). PMID: 8012607

GO terms

Cross References

Contributing Member Database Entries
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.