D
IPR007604

CP2 transcription factor

InterPro entry
Short nameCP2

Description

This entry represents a domain found in animal and fungal Grh/CP2 transcription factors (TFs), key regulators of epithelial differentiation, organ development and skin barrier formation. The Grh/CP2 family of TFs comprises two distinct divisions, CP2 (CCAAT box-binding protein 2) and Grh (grainyhead). Proteins of the CP2 subfamily are generally expressed ubiquitously, while the expression pattern of the Grh subfamily is rather tissue- and developmental stage specific. All Grh/CP2 family members share a common domain architecture characterized by an intrinsically unstructured N-terminal transactivation domain (TAD), a conserved DNA-binding domain (DB, also termed CP2 binding domain), and a C-terminal dimerization domain (DD). The Grh/CP2 DB domain contains an immunoglobulin (Ig)-like core with two long, twisted antiparallel β sheets of five and six strands, respectively. This core is decorated by three α helices and a series of surface loops
[2, 3, 1]
.

References

1.Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family. Ming Q, Roske Y, Schuetz A, Walentin K, Ibraimi I, Schmidt-Ott KM, Heinemann U. Nucleic Acids Res. 46, 2082-2095, (2018). View articlePMID: 29309642

2.Grainy head and its target genes in epithelial morphogenesis and wound healing. Wang S, Samakovlis C. Curr Top Dev Biol 98, 35-63, (2012). PMID: 22305158

3.The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers. Pare A, Kim M, Juarez MT, Brody S, McGinnis W. PLoS One 7, e36254, (2012). PMID: 22590528

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