F
IPR008017

Delta-hexatoxin

InterPro entry
Short nameDelta-hexatoxin

Description

Delta-hexatoxin (also known as delta-atracotoxin) is an arachnid toxin that produces potentially fatal neurotoxic symptoms in primates by slowing the inactivation of voltage-gated sodium channels
[1]
. Effects are an increase in resting tension, a muscle fasciculation and a decrease in indirect twitch tension. In vivo, it is lethal to both vertebrates and insects
[2]
. Its structure comprises a core β-region containing a triple-stranded a thumb-like extension protruding from the β-region and a C-terminal helix. The β-region contains a cysteine knot motif, a feature seen in other neurotoxic polypeptides
[1]
.

References

1.The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel. Fletcher JI, Chapman BE, Mackay JP, Howden ME, King GF. Structure 5, 1525-35, (1997). View articlePMID: 9384567

2.Isolation of delta-missulenatoxin-Mb1a, the major vertebrate-active spider delta-toxin from the venom of Missulena bradleyi (Actinopodidae). Gunning SJ, Chong Y, Khalife AA, Hains PG, Broady KW, Nicholson GM. FEBS Lett 554, 211-8, (2003). View articlePMID: 14596942

GO terms

biological process

  • None

Cross References

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