F
IPR008046

DNA replication licensing factor Mcm3

InterPro entry
Short nameMcm3
Overlapping
homologous
superfamilies
 
family relationships

Description

The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm3 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring
[2]
. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replication
[4, 3, 1]
. During G1-S phase, MCM2-7 complex is activated to unwind the double stranded DNA and plays an important role in DNA replication forks elongation
[1]
.

The components of the MCM2-7 complex are:


 * DNA replication licensing factor MCM2,
IPR008045

 * DNA replication licensing factor MCM3,
IPR008046

 * DNA replication licensing factor MCM4,
IPR008047

 * DNA replication licensing factor MCM5,
IPR008048

 * DNA replication licensing factor MCM6,
IPR008049

 * DNA replication licensing factor MCM7,
IPR008050


References

1.Control over DNA replication in time and space. Symeonidou IE, Taraviras S, Lygerou Z. FEBS Lett. 586, 2803-12, (2012). View articlePMID: 22841721

2.Structure and mechanism of helicases and nucleic acid translocases. Singleton MR, Dillingham MS, Wigley DB. Annu. Rev. Biochem. 76, 23-50, (2007). View articlePMID: 17506634

3.A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Evrin C, Clarke P, Zech J, Lurz R, Sun J, Uhle S, Li H, Stillman B, Speck C. Proc. Natl. Acad. Sci. U.S.A. 106, 20240-5, (2009). View articlePMID: 19910535

4.Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF. Cell 139, 719-30, (2009). View articlePMID: 19896182

GO terms

Cross References

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