IPR008253
Marvel domain
InterPro entry
Short name | Marvel |
Description
This entry represents the ~130-residue MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain. The MARVEL domain is a module with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families. All described MARVEL domain-containing proteins are consistent with the M-shaped topology: four transmembrane-helix region architecture with cytoplasmic N- and C-terminal regions. Their function could be related to cholesterol-rich membrane apposition events in a variety of cellular processes, such as biogenesis of vesicular transport carriers or tight junction regulation
[1].
References
1.MARVEL: a conserved domain involved in membrane apposition events. Sanchez-Pulido L, Martin-Belmonte F, Valencia A, Alonso MA. Trends Biochem. Sci. 27, 599-601, (2002). View articlePMID: 12468223
GO terms
Cross References
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