S
IPR008261

Iodothyronine deiodinase, active site

InterPro entry
Short nameIodothyronine_deiodinase_AS

Description

Iodothyronine deiodinase (
1.97.1.10
) (DI)
[1]
is the vertebrate enzyme responsible for the deiodination of the prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). All known DI are proteins of about 250 residues that contain a selenocysteine at their active site. Three types of DI are known, type II is essential for providing the brain with the appropriate levels of T3 during the critical period of development, and type III is essential for the regulation of thyroid hormone inactivation during embryological development.

This signature found in the central part of the enzyme, which contains the active site selenocysteine.

References

1.Cloning of a cDNA for the type II iodothyronine deiodinase. Davey JC, Becker KB, Schneider MJ, St Germain DL, Galton VA. J. Biol. Chem. 270, 26786-9, (1995). View articlePMID: 7592917

GO terms

biological process

  • None

cellular component

  • None

Cross References

Contributing Member Database Entry
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