F
IPR008428

Chondroitin N-acetylgalactosaminyltransferase

InterPro entry
Short nameChond_GalNAc

Description

This family represents Chondroitin N-acetylgalactosaminyltransferase. Proteins have a type II transmembrane topology. The enzyme is involved in the biosynthetic initiation and elongation of chondroitin sulphate and is the key enzyme responsible for the selective chain assembly of chondroitin/dermatan sulphate on the linkage region tetrasaccharide common to various proteoglycans containing chondroitin/dermatan sulphate or heparin/heparan sulphate chains
[1, 2]
.

References

1.Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate. Uyama T, Kitagawa H, Tamura Ji J, Sugahara K. J. Biol. Chem. 277, 8841-6, (2002). View articlePMID: 11788602

2.Molecular cloning and expression of a human chondroitin synthase. Kitagawa H, Uyama T, Sugahara K. J. Biol. Chem. 276, 38721-6, (2001). View articlePMID: 11514575

GO terms

Cross References

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