F
IPR008491

CDK5 regulatory subunit-associated protein 3

InterPro entry
Short nameCDK5RAP3

Description

CDK5RAP3 (also known as C53 or LZAP) serves as a probable tumour suppressor initially identified as a CDK5R1 interactor controlling cell proliferation
[1, 6]
. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation
[2, 3]
. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint
[4, 5]
. It has been shown to bind Wip1 and stimulates its phosphatase activity
[7]
.

References

1.A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart. Chen J, Liu B, Liu Y, Han Y, Yu H, Zhang Y, Lu L, Zhen Y, Hui R. Biochem. Biophys. Res. Commun. 294, 161-6, (2002). View articlePMID: 12054757

2.LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Wang J, An H, Mayo MW, Baldwin AS, Yarbrough WG. Cancer Cell 12, 239-51, (2007). View articlePMID: 17785205

3.A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. Wu J, Lei G, Mei M, Tang Y, Li H. J. Biol. Chem. 285, 15126-36, (2010). View articlePMID: 20228063

4.Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. Jiang H, Luo S, Li H. J. Biol. Chem. 280, 20651-9, (2005). View articlePMID: 15790566

5.Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation. Jiang H, Wu J, He C, Yang W, Li H. Cell Res. 19, 458-68, (2009). View articlePMID: 19223857

6.Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein. Xie YH, He XH, Tang YT, Li JJ, Pan ZM, Qin WX, Wan DF, Gu JR. Cell Res. 13, 83-91, (2003). View articlePMID: 12737517

7.LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro. Wamsley JJ, Issaeva N, An H, Lu X, Donehower LA, Yarbrough WG. Cell Cycle 16, 213-223, (2017). View articlePMID: 28027003

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