D
IPR008598

Drought induced 19 protein type, zinc-binding domain

InterPro entry
Short nameDi19_Zn-bd

Description

This zinc-binding domain is found in plant drought induced 19 (Di19) proteins, animal E3 ubiquitin-protein ligases (RNF114/KCMF1/RNF138/RNF125/RNF166) and transcriptional repressors (ZEB1/ZEB2). Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought
[1]
. KCMF1 and RNF114 are E3 ubiquitin-protein ligases
[2, 3]
, while ZEB1 represses transcription by binding to the E box (5'-CANNTG-3')
[4]
. In RNF114, this domain has been shown to be essential for mono-ADPr-dependent recruitment to DNA lesions
[5]
.

References

1.Abscisic acid-dependent and -independent regulation of gene expression by progressive drought in Arabidopsis thaliana. Gosti F, Bertauche N, Vartanian N, Giraudat J. Mol. Gen. Genet. 246, 10-8, (1995). View articlePMID: 7823904

2.FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric cancers. Jang JH. FEBS Lett. 578, 21-5, (2004). View articlePMID: 15581609

3.ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.). Han J, Kim YL, Lee KW, Her NG, Ha TK, Yoon S, Jeong SI, Lee JH, Kang MJ, Lee MG, Ryu BK, Baik JH, Chi SG. Cell Death Differ. 20, 1055-67, (2013). View articlePMID: 23645206

4.The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A, Waldvogel B, Vannier C, Darling D, zur Hausen A, Brunton VG, Morton J, Sansom O, Schuler J, Stemmler MP, Herzberger C, Hopt U, Keck T, Brabletz S, Brabletz T. Nat. Cell Biol. 11, 1487-95, (2009). View articlePMID: 19935649

5.Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling. Longarini EJ, Dauben H, Locatelli C, Wondisford AR, Smith R, Muench C, Kolvenbach A, Lynskey ML, Pope A, Bonfiglio JJ, Jurado EP, Fajka-Boja R, Colby T, Schuller M, Ahel I, Timinszky G, O'Sullivan RJ, Huet S, Matic I. Mol Cell S1097-2765(23)00240-X, (2023). PMID: 37116497

Cross References

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