H
IPR009061

Putative DNA-binding domain superfamily

InterPro entry
Short nameDNA-bd_dom_put_sf
Overlapping entries
 
Mu-type HTH domain (IPR003314)
SKI/SNO/DAC domain (IPR003380)
Excisionase-like (IPR012884)

Description

A putative DNA-binding domain with a conserved structure is found in several different protein families. The core structure of the domain consists of a three-helical fold that is architecturally similar to that of the "winged-helix" fold, but is topologically distinct. Representatives of this domain can be found in domains B1 and B5 from the beta subunit of phenylalanine-tRNA synthetases
[1]
, the C-terminal region of the DNA/RPA-binding domain of the DNA excision repair factor XPA
[2]
, the N-terminal domain of the transcriptional activators BmrR and MtaN
[3]
, the most conserved domain of the retinal development protein Dachshund
[4]
, and the DNA-binding domain of the gpNU1 subunit from the bacteriophage lambda viral packing protein terminase
[5]
.

References

1.Structure at 2.6 A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese. Fishman R, Ankilova V, Moor N, Safro M. Acta Crystallogr. D Biol. Crystallogr. 57, 1534-44, (2001). View articlePMID: 11679717

2.Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. Buchko GW, Daughdrill GW, de Lorimier R, Rao B K, Isern NG, Lingbeck JM, Taylor JS, Wold MS, Gochin M, Spicer LD, Lowry DF, Kennedy MA. Biochemistry 38, 15116-28, (1999). View articlePMID: 10563794

3.Crystal structure of the transcription activator BmrR bound to DNA and a drug. Heldwein EE, Brennan RG. Nature 409, 378-82, (2001). View articlePMID: 11201751

4.Structure of the retinal determination protein Dachshund reveals a DNA binding motif. Kim SS, Zhang RG, Braunstein SE, Joachimiak A, Cvekl A, Hegde RS. Structure 10, 787-95, (2002). View articlePMID: 12057194

5.Insights into specific DNA recognition during the assembly of a viral genome packaging machine. de Beer T, Fang J, Ortega M, Yang Q, Maes L, Duffy C, Berton N, Sippy J, Overduin M, Feiss M, Catalano CE. Mol. Cell 9, 981-91, (2002). View articlePMID: 12049735

Cross References

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