IPR009223
Adenomatous polyposis coli protein repeat
InterPro entry
Short name | APC_rpt |
Description
This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin
[1].
References
1.Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin. Nakagawa H, Murata Y, Koyama K, Fujiyama A, Miyoshi Y, Monden M, Akiyama T, Nakamura Y. Cancer Res. 58, 5176-81, (1998). View articlePMID: 9823329
GO terms
Contributing Member Database Entry
- Pfam:PF05923