F
IPR009348

Nitrogen permease regulator 2-like

InterPro entry
Short nameNPR2-like

Description

This family of regulators are involved in post-translational control of nitrogen permease. In mammals, members may act as a tumour suppressor that suppresses cell growth and enhances sensitivity to various anticancer drugs
[1, 2]
.

References

1.TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. Kurata A, Katayama R, Watanabe T, Tsuruo T, Fujita N. Cancer Sci. 99, 1827-34, (2008). View articlePMID: 18616680

2.A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex. Neklesa TK, Davis RW. PLoS Genet. 5, e1000515, (2009). View articlePMID: 19521502

Further reading

3. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM. Science 340, 1100-6, (2013). View articlePMID: 23723238

Cross References

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