IPR009447
Phosphatidylinositol anchor biosynthesis protein PIGW/GWT1
InterPro entry
Short name | PIGW/GWT1 |
Description
Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. PIGW and the yeast homologue GWT1 are involved in the addition of the acyl-chain to inositol in an early step of GPI biosynthesis
[1]. Mutations in PIGW are associated with West syndrome and hyperphosphatasia with mental retardation syndrome
[2].
References
1.GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast. Umemura M, Okamoto M, Nakayama K, Sagane K, Tsukahara K, Hata K, Jigami Y. J. Biol. Chem. 278, 23639-47, (2003). View articlePMID: 12714589
2.Glycosylphosphatidylinositol (GPI) anchor deficiency caused by mutations in PIGW is associated with West syndrome and hyperphosphatasia with mental retardation syndrome. Chiyonobu T, Inoue N, Morimoto M, Kinoshita T, Murakami Y. J. Med. Genet. 51, 203-7, (2014). View articlePMID: 24367057
GO terms
biological process
molecular function
cellular component
Contributing Member Database Entries
- Pfam:PF06423
- PIRSF:PIRSF017321
- PANTHER:PTHR20661