F
IPR009447

Phosphatidylinositol anchor biosynthesis protein PIGW/GWT1

InterPro entry
Short namePIGW/GWT1

Description

Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. PIGW and the yeast homologue GWT1 are involved in the addition of the acyl-chain to inositol in an early step of GPI biosynthesis
[1]
. Mutations in PIGW are associated with West syndrome and hyperphosphatasia with mental retardation syndrome
[2]
.

References

1.GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast. Umemura M, Okamoto M, Nakayama K, Sagane K, Tsukahara K, Hata K, Jigami Y. J. Biol. Chem. 278, 23639-47, (2003). View articlePMID: 12714589

2.Glycosylphosphatidylinositol (GPI) anchor deficiency caused by mutations in PIGW is associated with West syndrome and hyperphosphatasia with mental retardation syndrome. Chiyonobu T, Inoue N, Morimoto M, Kinoshita T, Murakami Y. J. Med. Genet. 51, 203-7, (2014). View articlePMID: 24367057

GO terms

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