F
IPR009652

Programmed cell death protein 10

InterPro entry
Short namePDCD10
Overlapping
homologous
superfamilies
 

Description

Programmed cell death 10 protein (PDCD10/CCM3) is part of the CCM complex and is required for neuronal migration
[2]
. It also has roles outside of this complex
[1]
, it is crucial in vascularization and in angiogenesis as it functions in vessel permeability and stability
[4]
. PDCD10/CCM3 was originally discovered to be upregulated during granulocyte apoptosis and is thought to play a role in cell death
[1]
. However, a specific role for PDCD10 in cell survival is not clear as both pro-survival and pro-apoptotic effects have been reported
[4, 3]
. PDCD10/CCM3 contains an N-terminal dimerisation domain and a C-terminal focal adhesion targeting-homology (FAT-H) domain
[3]
.

There are three CCM proteins: CCM1 (also known as KRIT1), CCM2 (also known as OSM and malcavernin) and CCM3 (also known as PDCD10). Mutations in the genes encoding CCM proteins cause cerebral cavernous malformations (CCMs), a disease characterised by dilated leaky blood vessels, especially in the neurovasculature, that result in increased risk of stroke, focal neurological defects and seizures. The CCM proteins can form a trimeric complex. They can also interact with a range of signaling, cytoskeletal and adaptor proteins that may account for their roles in a range of basic cellular processes including cell adhesion, migration, polarity and apoptosis
[3]
.

References

1.cDNA cloning and expression of an apoptosis-related gene, humanTFAR15 gene. Wang Y, Liu H, Zhang Y, Ma D. Sci. China, C, Life Sci. 42, 323-9, (1999). View articlePMID: 20229348

2.Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Louvi A, Nishimura S, Gunel M. Development 141, 1404-15, (2014). View articlePMID: 24595293

3.Cerebral cavernous malformation proteins at a glance. Draheim KM, Fisher OS, Boggon TJ, Calderwood DA. J. Cell. Sci. 127, 701-7, (2014). View articlePMID: 24481819

4.Downregulation of programmed cell death 10 is associated with tumor cell proliferation, hyperangiogenesis and peritumoral edema in human glioblastoma. Lambertz N, El Hindy N, Kreitschmann-Andermahr I, Stein KP, Dammann P, Oezkan N, Mueller O, Sure U, Zhu Y. BMC Cancer 15, 759, (2015). PMID: 26490252

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