IPR010240
Cysteine desulfurase IscS
InterPro entry
Short name | Cys_deSase_IscS |
Overlapping homologous superfamilies | |
family relationships |
Description
This entry represents cysteine deusulfurase (IscS), one of several cysteine desulfurases from a larger protein family designated (misleadingly, in this case) class V aminotransferases. IscS is one of at least 6 enzymes characteristic of the IscSUA-hscAB-fsx system of iron-sulphur cluster assembly
[1, 2, 3]. In M. tuberculosis this enzyme is associated with oxidative stress defence
[3].
References
1.Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo. Lauhon CT, Skovran E, Urbina HD, Downs DM, Vickery LE. J. Biol. Chem. 279, 19551-8, (2004). View articlePMID: 14978044
2.Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions. Ikeuchi Y, Shigi N, Kato J, Nishimura A, Suzuki T. Mol. Cell 21, 97-108, (2006). View articlePMID: 16387657
GO terms
biological process
molecular function
cellular component
- None