F
IPR010240

Cysteine desulfurase IscS

InterPro entry
Short nameCys_deSase_IscS
Overlapping
homologous
superfamilies
 
family relationships

Description

This entry represents cysteine deusulfurase (IscS), one of several cysteine desulfurases from a larger protein family designated (misleadingly, in this case) class V aminotransferases. IscS is one of at least 6 enzymes characteristic of the IscSUA-hscAB-fsx system of iron-sulphur cluster assembly
[1, 2, 3]
. In M. tuberculosis this enzyme is associated with oxidative stress defence
[3]
.

References

1.Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo. Lauhon CT, Skovran E, Urbina HD, Downs DM, Vickery LE. J. Biol. Chem. 279, 19551-8, (2004). View articlePMID: 14978044

2.Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions. Ikeuchi Y, Shigi N, Kato J, Nishimura A, Suzuki T. Mol. Cell 21, 97-108, (2006). View articlePMID: 16387657

3.The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defence. Rybniker J, Pojer F, Marienhagen J, Kolly GS, Chen JM, van Gumpel E, Hartmann P, Cole ST. Biochem. J. 459, 467-78, (2014). PMID: 24548275

GO terms

Cross References

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