F
IPR010347

Tyrosyl-DNA phosphodiesterase I

InterPro entry
Short nameTdp1

Description

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate
[1, 2]
.

References

1.Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1. Inamdar KV, Pouliot JJ, Zhou T, Lees-Miller SP, Rasouli-Nia A, Povirk LF. J. Biol. Chem. 277, 27162-8, (2002). View articlePMID: 12023295

2.Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks. Zhou T, Akopiants K, Mohapatra S, Lin PS, Valerie K, Ramsden DA, Lees-Miller SP, Povirk LF. DNA Repair (Amst.) 8, 901-11, (2009). View articlePMID: 19505854

Further reading

3. Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages. Interthal H, Chen HJ, Champoux JJ. J. Biol. Chem. 280, 36518-28, (2005). View articlePMID: 16141202

GO terms

Cross References

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