F
IPR010451

Acetoacetate decarboxylase

InterPro entry
Short nameAcetoacetate_decarboxylase
Overlapping
homologous
superfamilies
 
family relationships

Description

Acetoacetate decarboxylase (ADC) is involved in solventogenesis in certain bacteria, which occurs at the end of the exponential growth phase when there is a metabolic switch from classical sugar fermentation with the production of acetate and butyrate to the re-internalisation and oxidation of these acids to acetate and butanol
[1]
. In Clostridium, SpoOA controls the switch from acid to solvent production. A SpoAO-binding motif occurs in the gene encoding ADC
[2]
.

This family also contains the fungal decarboxylase DEC1 encoded by the Tox1B locus, which along with the Tox1A gene product is required for the production of the polyketide T-toxin. The pathogenic fungus Cochliobolus heterostrophus (Drechslera maydis) requires the T-toxin for high virulence to maize with T-cytoplasm
[3]
.

References

1.Changes in protein synthesis and identification of proteins specifically induced during solventogenesis in Clostridium acetobutylicum. Schaffer S, Isci N, Zickner B, Durre P. Electrophoresis 23, 110-21, (2002). View articlePMID: 11824611

2.Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia. Ravagnani A, Jennert KC, Steiner E, Grunberg R, Jefferies JR, Wilkinson SR, Young DI, Tidswell EC, Brown DP, Youngman P, Morris JG, Young M. Mol. Microbiol. 37, 1172-85, (2000). View articlePMID: 10972834

3.A decarboxylase encoded at the Cochliobolus heterostrophus translocation-associated Tox1B locus is required for polyketide (T-toxin) biosynthesis and high virulence on T-cytoplasm maize. Rose MS, Yun SH, Asvarak T, Lu SW, Yoder OC, Turgeon BG. Mol. Plant Microbe Interact. 15, 883-93, (2002). PMID: 12236595

GO terms

biological process

  • None

molecular function

cellular component

  • None

Cross References

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