IPR010599
Connector enhancer of kinase suppressor of ras 2/3 domain
InterPro entry
Short name | CNK2/3_dom |
Description
This region is found in Connector enhancer of kinase suppressor of ras 2 (CNK2), Connector enhancer of kinase suppressor of ras 3 (CNK3) and CNK3/IPCEF1 fusion protein. This domain of unknown function is situated between the PDZ
IPR001478 and PH
IPR001849 domains in CNK2 and CNK3/IPCEF1 proteins and after the PDZ domain in CNK3 (which does not have a PH domain). CNK2 is predominantly expressed in neural tissues, being critical for postsynaptic density morphology, implicated in X-linked intellectual disability (ID). CNK2 was first described as a regulator of Ras/MAPK signalling by binding to the Ras effector RAF that lead to further studies concluding that it act as a scaffold for multiple signal cascades. It is able to direct the localisation of regulatory proteins within the cell and influences the behaviour of important regulatory molecules
[1, 3]. CNK3 regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression, acting as a scaffold protein that coordinates the assembly of an ENaC-regulatory complex (ERC)
[2]. CNK3/IPCEF1 is required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration
[4].
References
1.Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. Lanigan TM, Liu A, Huang YZ, Mei L, Margolis B, Guan KL. FASEB J. 17, 2048-60, (2003). View articlePMID: 14597674
2.Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D. J Biol Chem 287, 33014-25, (2012). PMID: 22851176
GO terms
biological process
molecular function
- None
cellular component
Contributing Member Database Entry
- Pfam:PF06663