F
IPR010968

Ion-translocating oxidoreductase complex subunit E

InterPro entry
Short nameRnfE
family relationships

Description

The six-subunit complex RnfABCDGE in Rhodobacter capsulatus (Rhodopseudomonas capsulata) encodes a NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation
[1]
. A closely related complex in Escherichia coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized
[2]
. The Rnf complex is ferredoxin:NAD+ oxidoreductase that appears to pump different ions in different bacteria. In Clostridium ljungdahlii and Desulfovibrio alaskensis functions as a proton pump whose activity is important for growth
[4, 3]
, whereas in Acetobacterium woodii functions as a Na(+)-translocating electron transport chain
[5]
.

This family represents the subunit E of Rnf complexes.

References

1.Overexpression in Escherichia coli of the rnf genes from Rhodobacter capsulatus--characterization of two membrane-bound iron-sulfur proteins. Jouanneau Y, Jeong HS, Hugo N, Meyer C, Willison JC. Eur. J. Biochem. 251, 54-64, (1998). View articlePMID: 9492268

2.A reducing system of the superoxide sensor SoxR in Escherichia coli. Koo MS, Lee JH, Rah SY, Yeo WS, Lee JW, Lee KL, Koh YS, Kang SO, Roe JH. EMBO J. 22, 2614-22, (2003). View articlePMID: 12773378

3.The role of Rnf in ion gradient formation in Desulfovibrio alaskensis. Wang L, Bradstock P, Li C, McInerney MJ, Krumholz LR. PeerJ 4, e1919, (2016). View articlePMID: 27114876

4.The Rnf complex of Clostridium ljungdahlii is a proton-translocating ferredoxin:NAD+ oxidoreductase essential for autotrophic growth. Tremblay PL, Zhang T, Dar SA, Leang C, Lovley DR. MBio 4, e00406-12, (2012). View articlePMID: 23269825

5.The ferredoxin:NAD+ oxidoreductase (Rnf) from the acetogen Acetobacterium woodii requires Na+ and is reversibly coupled to the membrane potential. Hess V, Schuchmann K, Muller V. J. Biol. Chem. 288, 31496-502, (2013). View articlePMID: 24045950

GO terms

molecular function

  • None

cellular component

Cross References

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