IPR010997
HRDC-like superfamily
InterPro entry
Short name | HRDC-like_sf |
Overlapping entries |
Description
This superfamily represents the HRDC (helicase and RNaseD C-terminal) domain, which comprises two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein.
The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM (previously known as Werner and Bloom syndrome proteins)
[1]. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed α-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.
References
1.The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins. Liu Z, Macias MJ, Bottomley MJ, Stier G, Linge JP, Nilges M, Bork P, Sattler M. Structure 7, 1557-66, (1999). View articlePMID: 10647186
2.Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex. Todone F, Brick P, Werner F, Weinzierl RO, Onesti S. Mol. Cell 8, 1137-43, (2001). View articlePMID: 11741548
3.Structures of complete RNA polymerase II and its subcomplex, Rpb4/7. Armache KJ, Mitterweger S, Meinhart A, Cramer P. J. Biol. Chem. 280, 7131-4, (2005). View articlePMID: 15591044
GO terms
biological process
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- SUPERFAMILY:SSF47819
Representative structure
1go3: Structure of an archeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex