H
IPR010997

HRDC-like superfamily

InterPro entry
Short nameHRDC-like_sf
Overlapping entries
 
HRDC domain (IPR002121)

Description

This superfamily represents the HRDC (helicase and RNaseD C-terminal) domain, which comprises two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein.

The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM (previously known as Werner and Bloom syndrome proteins)
[1]
. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed α-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.

The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation α-hairpin
[3, 2]
.

References

1.The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins. Liu Z, Macias MJ, Bottomley MJ, Stier G, Linge JP, Nilges M, Bork P, Sattler M. Structure 7, 1557-66, (1999). View articlePMID: 10647186

2.Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex. Todone F, Brick P, Werner F, Weinzierl RO, Onesti S. Mol. Cell 8, 1137-43, (2001). View articlePMID: 11741548

3.Structures of complete RNA polymerase II and its subcomplex, Rpb4/7. Armache KJ, Mitterweger S, Meinhart A, Cramer P. J. Biol. Chem. 280, 7131-4, (2005). View articlePMID: 15591044

GO terms

cellular component

  • None

Cross References

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