F
IPR011179

Isopentenyl-diphosphate delta-isomerase, FMN-dependent

InterPro entry
Short nameIPdP_isomerase
Overlapping
homologous
superfamilies
 

Description

This entry represents the bacterial and archaeal isopentenyl-diphosphate delta-isomerase (IPP isomerase). IPP isomerase catalyses the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), and is a key enzyme in the biosynthesis of isoprenoids via the mevalonate pathway. The bacterial and archaeal IPP isomerase (type 2 enzyme) differs from that found in eukaryotes (type 1 enzyme), and requires NADPH, magnesium, and FMN for activity
[1, 2]
.

References

1.Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae. Yamashita S, Hemmi H, Ikeda Y, Nakayama T, Nishino T. Eur. J. Biochem. 271, 1087-93, (2004). View articlePMID: 15009187

2.Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis. Steinbacher S, Kaiser J, Gerhardt S, Eisenreich W, Huber R, Bacher A, Rohdich F. J. Mol. Biol. 329, 973-82, (2003). View articlePMID: 12798687

GO terms

Cross References

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