IPR011179
Isopentenyl-diphosphate delta-isomerase, FMN-dependent
InterPro entry
Short name | IPdP_isomerase |
Overlapping homologous superfamilies |
Description
This entry represents the bacterial and archaeal isopentenyl-diphosphate delta-isomerase (IPP isomerase). IPP isomerase catalyses the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), and is a key enzyme in the biosynthesis of isoprenoids via the mevalonate pathway. The bacterial and archaeal IPP isomerase (type 2 enzyme) differs from that found in eukaryotes (type 1 enzyme), and requires NADPH, magnesium, and FMN for activity
[1, 2].
References
1.Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae. Yamashita S, Hemmi H, Ikeda Y, Nakayama T, Nishino T. Eur. J. Biochem. 271, 1087-93, (2004). View articlePMID: 15009187
2.Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis. Steinbacher S, Kaiser J, Gerhardt S, Eisenreich W, Huber R, Bacher A, Rohdich F. J. Mol. Biol. 329, 973-82, (2003). View articlePMID: 12798687
GO terms
biological process
molecular function
cellular component
- None
Cross References
ENZYME
Genome Properties
Contributing Member Database Entries
- CDD:cd02811
- PANTHER:PTHR43665
- HAMAP:MF_00354
- PIRSF:PIRSF003314
- NCBIfam:TIGR02151
Representative structure
1p0k: IPP:DMAPP isomerase type II apo structure