IPR011263
DNA-directed RNA polymerase, RpoA/D/Rpb3-type
InterPro entry
Short name | DNA-dir_RNA_pol_RpoA/D/Rpb3 |
Overlapping homologous superfamilies |
Description
The core of the bacterial RNA polymerase (RNAP) consists of four subunits, two alpha, a beta and a beta', which are conserved from bacteria to mammals. The alpha subunit (RpoA) initiates RNAP assembly by dimerising to form a platform on which the beta subunits can interact, and plays a direct role in promoter recognition
[3]. In eukaryotes, RNA polymerase (RNAP) II is responsible for all mRNA synthesis. RNAP-II consists of 12 subunits, where subunits Rpb3 and Rpb11 form a heterodimer that is functionally analogous to the bacterial RpoA homodimer
[2]. Archaeal RNAP closely resembles eukaryotic RNAP-II, and is composed of 12 subunits, of which D and L form a heterodimer resembling the Rpb3/Rpb11 and RpoA/RpoA dimers
[1].
The bacterial RpoA, eukaryotic Rpb3 and archaeal D subunits share sequence and structural motifs, and can be placed into a single family. These subunits also have unique sequence motifs, especially at their C-terminal ends, which are involved in promoter specificity, for example the CTD of the bacterial RNAP alpha subunit (
IPR011260).
References
1.Archaeal chromatin and transcription. Reeve JN. Mol. Microbiol. 48, 587-98, (2003). View articlePMID: 12694606
2.Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4). De Angelis R, Iezzi S, Bruno T, Corbi N, Di Padova M, Floridi A, Fanciulli M, Passananti C. FEBS Lett. 547, 15-9, (2003). View articlePMID: 12860379
3.UPs and downs in bacterial transcription initiation: the role of the alpha subunit of RNA polymerase in promoter recognition. Gourse RL, Ross W, Gaal T. Mol. Microbiol. 37, 687-95, (2000). View articlePMID: 10972792
GO terms
biological process
molecular function
cellular component
- None
Cross References
ENZYME