IPR011547
SLC26A/SulP transporter domain
InterPro entry
Short name | SLC26A/SulP_dom |
Description
This entry represents a conserved domain found in a group of sulphate transporters, known as the SLC26A/SulP family
[2, 3]. These proteins contain an N-terminal membrane domain and a C-terminal cytoplasmic STAS domain a STAS (sulfate transporter and anti-sigma factor antagonist) domain
[1]. This central domain is usually found next to the STAS domain (
IPR002645). Proteins containing this domain include:
* Neurospora crassa sulphate permease II (gene cys-14).
* Yeast sulphate permeases (genes SUL1 and SUL2).
* Rat sulphate anion transporter 1 (SAT-1).
* Mammalian DTDST, a probable sulphate transporter which, in human, is involved in the genetic disease, diastrophic dysplasia (DTD).
* Sulphate transporters 1, 2 and 3 from the legume Stylosanthes hamata.
* Human pendrin (gene PDS), which is involved in a number of hearing loss genetic diseases.
* Human protein DRA (Down-Regulated in Adenoma).
* Soybean early nodulin 70.
* Escherichia coli hypothetical protein ychM.
* Caenorhabditis elegans hypothetical protein F41D9.5.
* Neurospora crassa sulphate permease II (gene cys-14).
* Yeast sulphate permeases (genes SUL1 and SUL2).
* Rat sulphate anion transporter 1 (SAT-1).
* Mammalian DTDST, a probable sulphate transporter which, in human, is involved in the genetic disease, diastrophic dysplasia (DTD).
* Sulphate transporters 1, 2 and 3 from the legume Stylosanthes hamata.
* Human pendrin (gene PDS), which is involved in a number of hearing loss genetic diseases.
* Human protein DRA (Down-Regulated in Adenoma).
* Soybean early nodulin 70.
* Escherichia coli hypothetical protein ychM.
* Caenorhabditis elegans hypothetical protein F41D9.5.
References
1.The STAS domain - a link between anion transporters and antisigma-factor antagonists. Aravind L, Koonin EV. Curr. Biol. 10, R53-5, (2000). View articlePMID: 10662676
2.Similarities between a soybean nodulin, Neurospora crassa sulphate permease II and a putative human tumour suppressor. Sandal NN, Marcker KA. Trends Biochem. Sci. 19, 19, (1994). View articlePMID: 8140616
3.Isolation of a cDNA from Saccharomyces cerevisiae that encodes a high affinity sulphate transporter at the plasma membrane. Smith FW, Hawkesford MJ, Prosser IM, Clarkson DT. Mol. Gen. Genet. 247, 709-15, (1995). View articlePMID: 7616962
GO terms
Contributing Member Database Entry
- Pfam:PF00916