D
IPR011547

SLC26A/SulP transporter domain

InterPro entry
Short nameSLC26A/SulP_dom

Description

This entry represents a conserved domain found in a group of sulphate transporters, known as the SLC26A/SulP family
[2, 3]
. These proteins contain an N-terminal membrane domain and a C-terminal cytoplasmic STAS domain a STAS (sulfate transporter and anti-sigma factor antagonist) domain
[1]
. This central domain is usually found next to the STAS domain (
IPR002645
). Proteins containing this domain include:
 * Neurospora crassa sulphate permease II (gene cys-14).
 * Yeast sulphate permeases (genes SUL1 and SUL2).
 * Rat sulphate anion transporter 1 (SAT-1).
 * Mammalian DTDST, a probable sulphate transporter which, in human, is involved in the genetic disease, diastrophic dysplasia (DTD).
 * Sulphate transporters 1, 2 and 3 from the legume Stylosanthes hamata.
 * Human pendrin (gene PDS), which is involved in a number of hearing loss genetic diseases.
 * Human protein DRA (Down-Regulated in Adenoma).
 * Soybean early nodulin 70.
 * Escherichia coli hypothetical protein ychM.
 * Caenorhabditis elegans hypothetical protein F41D9.5.

References

1.The STAS domain - a link between anion transporters and antisigma-factor antagonists. Aravind L, Koonin EV. Curr. Biol. 10, R53-5, (2000). View articlePMID: 10662676

2.Similarities between a soybean nodulin, Neurospora crassa sulphate permease II and a putative human tumour suppressor. Sandal NN, Marcker KA. Trends Biochem. Sci. 19, 19, (1994). View articlePMID: 8140616

3.Isolation of a cDNA from Saccharomyces cerevisiae that encodes a high affinity sulphate transporter at the plasma membrane. Smith FW, Hawkesford MJ, Prosser IM, Clarkson DT. Mol. Gen. Genet. 247, 709-15, (1995). View articlePMID: 7616962

GO terms

biological process

  • None

molecular function

  • None

cellular component

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